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Although ingesting small to moderate amounts of caffeine usually results in pleasant feelings, larger amounts taken all at once or within a short period of time can cause or aggravate jitteriness, insomnia (especially in caffeine abstainers), nervousness, and anxiety (Bertasi et al., 2021

Brohee, O

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Addition of Se to L-T4 therapy may be appropriate in patients with low Se intake and mild or early stage HT