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In the obese trial cohort, 1 mg moved 24-hour heart rate by +0.7 bpm in the first week, essentially placebo. In a healthy lean Phase 1b group, the same dose raised heart rate by about 10 bpm, with a peak near 15 to 20 bpm around days 4 to 6. Lean, younger participants had more reactive heart-rate control than the sedentary, obese, and metabolically stressed trial population
Theranostics 8 , 50395058 (2018)
Mechanism of Action The mechanism of DSIP in the laboratory settings is believed to involve central nervous system (CNS) pathways related to sleep, Neuroendocrine regulation and sleep cycle modulation
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Separate KPV is sometimes used for short inflammatory events such as an acne flare or post-procedure irritation, then stopped when the event resolves
