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Jacob Neil (Consultant Internal Medicine Wellkins Medical Centre) Glucagon-like peptide-1 (GLP-1) analogue therapy has revolutionized the management of Type 2 Diabetes and chronic weight management

Rapid weight lossdefined as losing more than 1-2 pounds per weekplaces physiological stress on the body

Abstract This review addresses the role of semaglutide (SMG), a GLP-1 receptor agonist, in the treatment of obesity and its related comorbidities

[22] [23] These can identify underlying conditions contributing to weight gain and inform the most appropriate treatment pathway

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By leveraging translational insights from these data, we consider potential implications for clinical practice and propose avenues for further research