The biggest reductions were seen in men and in people who reported joint or muscle pain
Last updated: April 3, 2026 If you have lost significant weight through GLP-1 medications like Ozempic, Wegovy, or Mounjaro, you are not alone in wondering what comes next
While direct-to-consumer models offer clear benefits, they cannot replace the value of coordinated, longitudinal care
A phase 2 clinical trial, published in The New England Journal of Medicine, included 338 adults with a body mass index (BMI) of 30 or greater, or a BMI between 27 and 30, with at least one weight-related comorbidity to assess the efficacy and benefits of retatrutide
Reviewed May 2026
The FDA added semaglutide to its official drug shortage list