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In some embodiments, the otic formulation or composition comprises about 0.03% by weight of the silicon dioxide

Fisher M, VandenBranden M, Findlay K, Burchell B, Thummel K, Hall S, Wrighton SA: Tissue distribution and interindividual variation in human UDP-glucuronosyltransferase activity: relationship between UGT1A1 promoter genotype and variability in a liver bank

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If you do consider this approach, start with minimal doses of each and assess your response before increasing

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