[10] For mood disorders like bipolar depression, clinical research has experimented with doses ranging from 15 mg daily (which demonstrated antidepressant effects in small studies) up to 200-300 mg daily in divided doses for refractory cases
Prajakta Pushkar Shah, M.B.B.S., M.HTN
Efficacy should be hedged accordingly the trials tell us what the drug does in a controlled trial population, not what any individual using research material will experience
During the same period, there was a 2-fold increase in the proportions of users without type 2 diabetes but with a BMI of 30 kg/m2 or greater, or in those with a BMI of 27 to 30 kg/m2 and an obesity-related comorbid condition
Most people notice initial effects within the first few weeks, with more significant results appearing over several months
Many other factors, such as fitness goals and lifestyle demands, are also considered to ensure everyone is working toward the same outcome