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This receptor framework is important because it explains why studies measure clear endpoints like body weight change , waist measures , energy intake signals , and selected glycaemic and cardiometabolic markers over defined time windows

Clinical evidence includes stroke trials where 5 mg/day riboflavin, often in combination with other B vitamins, improved erythrocyte glutathione reductase activity and reduced the proportion of biochemically riboflavin-deficient patients, although clinical outcomes remain understudied (57)

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doi: 10.1016/j.exger.2022.111982

Anal Biochem 177:300306 [DOI] [PubMed] [Google Scholar] Demidchik V (2015) Mechanisms of oxidative stress in plants: from classical chemistry to cell biology