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These include: Nause Diarrhea Vomiting Constipation Reduced appetite Abdominal discomfort Possible unusual skin sensations, also called dysesthesia Serious GLP-1 Side Effects Most GLP-1 side effects are mild, but rare, serious problems can happen

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Because this is an area with notable unmet needs, especially in terms of pharmacological treatment options, further research investment is warranted

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Bedtime injection is not recommended due to the potential for metabolic activation to interfere with sleep onset and early sleep stages

Neurology 81(13):11591165 Rosser DA et al (2003) How sensitive to clinical change are ETDRS logMAR visual acuity measurements