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Most studies report an increased sensitivity to experimental pain and, therefore, a decreased pain threshold in depressed compared to non-depressed subjects especially when emotional aspects of experimental pain are taken into account (Ushinsky et al., 2013)

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It may also impair glutathiones ability to neutralize and help remove free radicals

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Current guidelines from the Menopause Society and ACOG support HRT as safe and appropriate for most healthy women under 60 within 10 years of menopause onset