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Active site residues U46, K48, Q81, and W136 are highlighted and shown as sticks

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13 Although evidence suggests that GLP-1 RAs may have neuroprotective properties and delay disease progression, this was based on a few small phase II studies

Interestingly, DFMC collapsed rapidly after being endocytosed in tumor cells, displaying a noticeably responsive-released behavior in the presence of GSH and an acidic microenvironment (GSH = 10 mM, pH = 6.5) (Figure 4D)