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Exenatide was the worlds first clinically used GLP-1RA, developed in 1995 and approved for the treatment of type 2 diabetes mellitus (T2DM) in 2005 due to its proven ability to regulate postprandial glucose levels effectively (DeFronzo et al., 2005

In addition, thioredoxin-interacting protein (TXNIP) is an important protein that mediates ROS and the NOD-like receptor protein 3 (NLRP3) inflammasome (78)

Scientific understanding, particularly in the context of new gene data, indicates its profound regenerative and protective actions

GLP-1 receptor agonists operate on several levels

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The design of this anchor trial matters immensely because it compares the combined mechanistic approach directly against a standard biologic therapy