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Obtain a blood chemistry profile that includes bicarbonate, creatinine, and potassium in all patients, and glucose in patients with type 2 diabetes mellitus on antidiabetic medication prior to initiating phentermine and topiramate extended-release capsules treatment and periodically during treatment [see Warnings and Precautions (5.7, 5.8,5.12)]

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Raw relative light unit (RLU) readings were expressed as the ratio of Venus to Nanoluc signals, and baseline-corrected BRET ratios normalised to vehicle readings to determine the agonist-induced effect

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