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Obtain a blood chemistry profile that includes bicarbonate, creatinine, and potassium in all patients, and glucose in patients with type 2 diabetes mellitus on antidiabetic medication prior to initiating phentermine and topiramate extended-release capsules treatment and periodically during treatment [see Warnings and Precautions (5.7, 5.8,5.12)]
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As your body responds to the medication's signals, cortisol and adrenaline levels may temporarily rise, constricting blood vessels and sensitizing pain pathways
Raw relative light unit (RLU) readings were expressed as the ratio of Venus to Nanoluc signals, and baseline-corrected BRET ratios normalised to vehicle readings to determine the agonist-induced effect