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Jastreboff AM , 2023, Triple hormone receptor agonist retatrutide for obesity a phase 2 trial, N Engl J Med 389 6 9

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When you see doctors who have fat squirting out where it has been injected, it is because they have injected too much fat

Under conditions of oral dysbiosis such as periodontitis, F.n can disseminate to distant sites, and its enrichment in the gut is a hallmark of a disrupted microbial state, rarely observed in healthy individuals (Connolly and Kelly, 2025

Its plasma levels decline significantly with age (from ~200ng/mL at 20 to ~80ng/mL at 60), making it a key compound for aging biology and regenerative research