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TB-500 is a synthetic fragment of thymosin beta-4 (residues 1723, sequence Ac-LKKTETQ) studied for its role in actin sequestration and cytoskeletal organization specifically the regulation of G-actin to F-actin polymerization balance that governs cell morphology and migration

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One attempt to better understand and clinically correlate some of the disparate findings described above is comparison of the total number of domains or symptoms produced by those who have had TBI with a comorbidity of posttraumatic stress disorder (PTSD), those with TBI without a PTSD comorbidity, and those with PTSD but with no history of TBI or concussion