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If proper titration starting at the lowest dose with gradual 4-week escalation still produces intolerable GI effects, split dosing may allow continued use of the medication rather than abandoning it entirely

Practice is better

J Hepatol (2019) 70:53144

A meta-analysis published in PMC concluded that weight regain is common and drug-dependent following discontinuation of anti-obesity pharmacotherapies, emphasising the need for sustained, long-term treatment strategies to manage obesity as a chronic disease

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