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Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family

Induction of the mitochondrial permeability transition causes release of the apoptogenic factor cytochrome c

ET-1, a vasoconstrictor peptide originating from endothelial cells, exerts its effects through endothelin receptors and is correlated with cardiovascular disease severity

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In addition to these canonical signaling pathways, recent single-cell transcriptomic studies have revealed marked heterogeneity in ferroptosis susceptibility among chondrocyte subpopulations in OA cartilage

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