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Vitamin B12 Deficiency: Insufficient dietary intake of B12 (common in vegetarians and vegans), Malabsorption due to conditions like pernicious anemia or gastrointestinal disorders (e.g., Crohns disease), Certain medications that interfere with B12 absorption can lead to deficiency

Placement on that list can make a bulk substance eligible for use in qualifying traditional compounding under section 503A