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A clinical study found that giving people bitter compounds in capsule form before meals helped them consume 14% fewer calories

Classically, it should not be used as a screening method for diagnosing asymptomatic patients and its use in patients with signs or symptoms is a subject of debate, given that ammonia is not specific for diagnosing HE

10.1210/jc.84.9.3117

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doi:10.1007/s00125-017-4491-0

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