Patients require referral to specialist (often Tier 3) weight management services
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Clinical trials show weight loss outcomes of up to 15%, with additional benefits including reduced A1C levels and cardiovascular improvements Key Benefits of GLP-1 Therapies: Enhanced insulin sensitivity Lower blood sugar levels Reduced visceral fat and improved lipid profiles Improved cardiovascular health Decreased inflammation linked to chronic disease Source: Glucagon-like peptide 1 in health and disease
(3) M.R.Safarinejad and S.Y.Hosseini (2008) Salvage of sildenafil failures with bremelanotide: a randomized, double-blind, placebo controlled study The Journal of Urology, 2008 Mar;179(3):1066-71
The patients who benefit most are those in steep deficits (1,2001,400 calories daily for women, 1,6001,800 for men) who present with elevated liver enzymes or fatigue despite adequate macronutrient intake
