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The more open TMD in the static exendin-4 bound cryo-EM structure was associated with fewer stable peptide contacts (Supplemental Table 1), relative to GLP-1 and oxyntomodulin, however, the cryo-EM map was lower resolution, which precluded modelling of some of the binding site (top of TM6, ECL3 and ECL1)

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Hybrid models, like those pursued by Empower and others, could become the norm