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References Badenhorst, T., Svirskis, D., Wilsher, T., & O'Sullivan, J

This may be explained by the findings of Albares and colleagues, Guinot and colleagues, and Kang and colleagues , who reported that pregnancy, use of hormonal contraception and lack of use of sunscreen are aggravating factors of melasma due to increase number and activity of melanocyte in epidermis

doi: 10.1016/j.heliyon.2023.e19763 202 RodriguezJBystrynJC

Over time, this supports a smoother and more uniform complexion

The maximum recommended concentration for use is 0.1%-0.6%

The affinity of SARS-CoV-2 for ACE2 receptors makes the virus prone to cause vascular infection that could explain atherosclerosis progression and arterial and venous thrombosis (Vinciguerra et al., 2020