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Lin YK, Fisher SJ, Pop-Busui R (2020) Hypoglycemia unawareness and autonomic dysfunction in diabetes: lessons learned and roles of diabetes technologies

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Compared to GLP-1, semaglutide carries a substitution of the alanine at position 8 with -aminoisobutyric acid (Aib) and acylation of the lysine at position 26 with a fatty di-acid side chain for extended half-life, which is linked via a linker sequence

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