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Reports of concerns in pediatric patients are overwhelmingly in the 10-18 age range, and mirror those of adults

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However, long-term risks such as rare adverse effects, metabolic effects over years, effects on bone, gallbladder, and pancreas need phase-3 trials and post-marketing surveillance to ensure the medication is safe for long-term use

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Then, gradually and thermodynamically, it moves to form the correct interface with the receptor

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I never thought I would be writing something like this publicly

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Pharmacol Rep

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Jastreboff AM, le Roux CW, Stefanski A, et al

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