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Medicare Part D Gross Spending on GLP-1s Increased Five-Fold Between 2019 and 2024, But Estimated Rebates of Around 50% Mean That Net Spending is Much Lower Gross Medicare Part D spending on GLP-1s in 2024 (not accounting for rebates) totaled $27.5 billion, a five-fold increase from 2019, reflecting an expansion in use of GLP-1s with more recent FDA approvals for type 2 diabetes

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N95 or equivalent respiratory protection is advised when working outside of containment

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Rigorous safety evaluation, development of human-relevant colonization models, and controlled early-phase clinical studies will be essential before engineered probiotics can be considered viable therapeutic candidates