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Thanks, Rosa Hi Aaron, Interesting article re nrf2 activation

PMID: 35666500

The exact magnitude of regain with retatrutide has not been published in detail yet, but the general pattern from semaglutide and tirzepatide studies shows that approximately one-third to two-thirds of lost weight returns within 12 months of discontinuation, particularly without lifestyle modifications

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The trial missed its primary endpoint, a global statistical test of cognition and function, with a p-value of 0.70 (topline release)

In addition, we calculated I 2 statistics and p value from Cochrans Q test to measure heterogeneity among studies