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Figure 3 Kynurenine was demonstrated to cross the BBB and was implicated in the pathophysiology of disorders marked by impulsivity, including schizophrenia, ADHD, cognitive disorders, drug addictions, and mania (205)

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The conformation of TM6-ECL3-TM7 has been correlated with the distinct signalling profiles of GLP-1 and exendin-P5, and along with the conformation of TM1, TM2 and ECL2, are key receptor domains important for GLP-1R cAMP signalling, and biased agonism 3, 13, 28, 29

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