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2018;315:E520E530
423 These findings further confirmed the central role of the CNS in regulating the anti-inflammatory effects of GLP-1RAs, highlighting the potential application of GLP-1RAs in anti-inflammatory treatment
These findingsoriginating from landmark trials such as EMPA-REG OUTCOME, LEADER, and SUSTAIN-6have led to substantial revisions in international guidelines from the European Society of Cardiology, American College of Cardiology, and American Heart Association, which now recommend the use of SGLT2i or GLP-1 RAs, often in conjunction with metformin
ClinicalTrials.gov (2026) 10
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