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374 Exendin-4 has also been shown to stimulate osteoblast activity and mitigate bone loss in an ovariectomized mouse model

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"For patients needing these medications, especially those with diabetes, the current guidelines may need to be reevaluated." The study highlights the need for evidence-based guidelines and interdisciplinary cooperation and has significant implications for clinical practice

Study selection The criteria for including studies in this meta-analysis were as follows: (1) (i) randomized controlled trials (RCTs) comparing different AOMs with placebo, including glucagon-like peptide 1 receptor agonist (GLP-1 RA), dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 RAs, GLP-1 and glucagon receptor (GCGR) dual-agonist, orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and bimagrumab

Researchers took a closer look at the results after the main study was completed, and these findings were shared at a major medical conference (the EASD congress) in September 2025

Reports from the European Medicines Agency (EMA) were due in November 2023, but the EMA asked for more data from manufacturers in December 2023, and final results are still unreleased [11, 31]