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The metabolites 3-oxoLCA and isoLCA were shown to inhibit T H 17 cell differentiation by binding to transcription factor retinoid-related orphan receptor (ROR) t (172, 173), while production of mitochondrial reactive oxygen species by isoalloLCA increased expression of FoxP3 and Treg cell differentiation (172) (Figure 1)

The exact contribution of particular CYP isoforms to APAP bioactivation varies and depends on the concentration of the drug

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Only one uncontrolled study evaluates erythromycin alone (20 mg/kg/day) as a prokinetic agent but the strength of this data is limited by the poor quality of the study (151)

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