i , Number of significant calcium events averaged per condition during 1-hour recording session following vehicle or liraglutide injection ( n = 6 mice per injection, paired t-test)
This difference stems from tirzepatide's dual mechanismit activates both GLP-1 and GIP receptors in the brain and gut, whereas semaglutide targets GLP-1 alone
Non-Invasive Treatment: Unlike surgical weight loss options, GLP-1 injections are non-invasive and require minimal downtime
Takasu M, Kishi S, Nagasu H, Kidokoro K, Brooks CR, Kashihara N
The nasal route facilitates non-invasive administration, avoiding the need for injections or complex delivery systems, which may simplify protocol designs during experimental procedures
Accessed June 10, 2013