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The best evidence for weight loss comes from a meta-analysis of 37 trials: a modest average reduction of about 1.2 kg (under 3 lbs), mostly in adults who are overweight
Lancet 397(10278):971984 Shi I, Khan SS, Yeh RW, Ho JE, Dahabreh IJ, Kazi DS (2025) Semaglutide Eligibility Across All Current Indications for US Adults
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