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Exendin-4-based GLP-1 receptor agonists The first GLP-1 receptor agonist to be used clinically was the recombinant form of the peptide exendin-4, called exenatide

Note: these are averages, suggesting that some patients did not lose as much weight, whilst others exceeded these numbers

Clinical trials like STEP 1 showed participants lost an average of 14.9% body weight over 68 weeks

Biochem Biophys Res Commun 298:779784 Mannucci E, Ognibene A, Cremasco F et al (2001) Effect of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels in obese nondiabetic subjects

Retatrutide is not expected to be used as a fixed cycle with a stop date

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