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Jiang Z, Wang Z, Chen L, Zhang C, Liao F, Wang Y, Wang Y, Luo P, Luo M, Shi C

In trials where semaglutide tablets was added on to metformin and/or sulfonylurea, basal insulin alone, or metformin in combination with basal insulin in patients with moderate renal impairment, severe hypoglycemia was not reported in any of the patients in the trial

10.1080/08923973.2018.1469145 111 WenC.CaoL.YuZ.LiuG.ZhangJ.XuX

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At present, there is no definitive evidence of the interaction between the circadian clock system and the GH/IGF-1 axis and the pathophysiological mechanism causing metabolic disorders