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The LH comprises two major neuronal populations, GABAergic and glutamatergic neurons, that play opposing and bidirectional roles in reward and feeding [810]

JAMA 2017;318:11824

doi: 10.3389/fncel.2025.1523773 20

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This cycle is activated by the combination of glutathione depletion, which increases the activity of -glutamyl cysteine synthetase, and cysteine deficiency, which prevents the high energy intermediate product -glutamyl phosphate (step 1) from being converted to -glutamyl cysteine (step 2)

Tirzepatide targets the GLP-1 receptor and another hormone called GIP