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Patients with a del15q genotype tend to have higher BMI (137, 176, 177) and HbA1c levels, despite similar values of glycemia, insulinemia, insulin resistance, body composition, metabolic profile, adipocyte size, resting energy expenditure, hyperphagia score, and levels of ghrelin compared to those with mUPD, suggesting a possible association between mUPD genotype and a more adverse metabolic profile, even when adjusted for BMI

The NHS has developed a 12-year implementation plan aimed at targeting high-risk obese patients, but without the necessary resources to fully support it

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Mounjaro EPAR Assessment Report (variation)

General optimization: Start conservative (10 units) and titrate to the minimum effective dose that produces your desired effects

Mounjaro is administered via subcutaneous injection