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First, physicians should be aware that GLP-1 RAs provide a variety of advantages beyond weight loss and glycemic control, especially for T2D patients with established cardiovascular disease, elevated CRP, elevated cardiovascular risk, MASLD/MASH, or chronic kidney disease

[1] [2] These symptoms typically diminish over time as the body adjusts to the medication

Concerning signs that require medical attention include: Spreading redness larger than a few inches Red streaks Severe or worsening pain Fever or chills Hives away from the site Facial or throat swelling Any breathing difficulty When symptoms worsen rather than improve, document the site with a photo and contact your clinician promptly so they can assess for infection or a true allergic response

Aligning treatment efficacy with patient goals may enhance long-term adherence. 19 Trial strengths: diverse cohort (19% Black, 26% Hispanic), real-world dosing (max tolerated, not fixed dose), and high treatment retention (~85%)