PMID: 38969654): NNMT inhibition alone improved grip strength by 40% in aged sedentary mice Combined with exercise, grip strength improved by 60% over sedentary controls Proteomic and metabolomic analyses revealed distinct molecular mechanisms from exercise Related Reading# Stay current on 5-Amino-1MQ research We summarize new studies, safety updates, and dosing insights delivered biweekly
KPV: Anti-Inflammatory Power Without Immunosuppression Mechanism of Action: KPV is a tripeptide fragment (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone (-MSH)
This phenomenon, sometimes called tolerance or dose creep, is reported anecdotally with tirzepatide, though the clinical trial data does not show significant tolerance development at fixed doses over 72 weeks
A lack of B12 can disrupt this process and impact how well the hair grows
Mol Biol Evol 19:10661082
Since interleukin 1-beta has been shown to be a key player in gouty inflammation (see under colchicine for acute gout, above), this agent has been studied in the treatment of gout attacks and appears to have been successful in preliminary study.14 Rilonacept (Arcalyst): This is a fusion protein which acts as a blocker of interleukin 1- beta, and it has a longer duration of action than Anakinra