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Reactive Oxygen Species (ROS) an oxygen-containing, free radical species

Acknowledgement The authors are grateful to Arkadiusz wiato for the help during the animal studies

Abstract Metabolic reprogramming has garnered significant attention in recent years due to its therapeutic potential in cancer treatment

Of note, almost half of patients treated with GLP-1-RAs also had pre-existing migraine as comorbidity (26.7% in the UCWM group), which could predispose them to worse (rather than better) headache outcomes [31], providing additional evidence of a favorable effect of GLP-1-RAs on headache improvement

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Updated June 2026 GLP-1 vs GLP-2 vs GLP-3: What's the Difference