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With the exception of very simple aliphatic acids such as valproic acid (VPA), these molecules conform to a common pharmacophore (Figure 1C), comprising a linker mimicking a lysine side chain, and a cap structure of variable size that makes additional interactions around the rim of the enzyme active site

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Moreover, recently it has been reported that the pathway governed by NE2FL2 is not only regulated by the proteasome but also by ATG (Jain et al., 2013)

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doi: 10.1093/jas/skab277