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reported for the first time that osteomalacia occurred in 4 patients who used phenytoin, primidone, and phenobarbitone for long-term antiseizure therapy, possibly because drug-mediated enzyme induction led to a significant increase in the degree of vitamin D inactivation (8)

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There are well-documented, relatively common loss-of-function variants in human OCT1, and genetic variation in OCT1 has been investigated by a number of groups in relation to pharmacokinetics, efficacy and GI intolerance [7, 2629]

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Oral Formulations: While most of these powerful drugs are currently injectables, companies are working hard to develop effective oral versions

In addition to the 95% CIs, the pooled effect size in CRC patients were significantly less than that in control group at 99% CIs (WMD (99% CIs) = 138.20 (261.17.18, 15.24), p = 0.004) (Fig