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Medication history: prior GLP-1, tirzepatide, insulin, or sulfonylurea use

Semaglutide, the active ingredient in Ozempic and Wegovy, was originally developed to help people lose 1522% of body weight in clinical trials

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Increases of GTP (2.4-fold in plasma), uridine, and xanthine (2.8- and 4.0-fold in blood, respectively) were also prominent (Table 1)

*In addition to NAD kinase, there are several lesser-known mechanisms of generating NADP, all of which depend on mitochondrial enzymes (e.g., NADP-linked malic enzyme, NADP-linked isocitrate dehydrogenase, NADP-linked glutamate dehydrogenase, nicotinamide nucleotide transhydrogenase)