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Surgical management is indicated for progressive scoliosis or progressive joint pain not responsive to non-operative management

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Methionine metabolism requires B6, B12, and folate to prevent homocysteine accumulation, which can cause fatigue and vascular inflammation if elevated

This means their manufacturing processes, analytical methods and impurity profiles may differ substantially

Mechanistically, TMAO may contribute to electrophysiological dysfunction by activating the protein kinase R-like endoplasmic reticulum kinase (PERK)/IRE1 axis, leading to increased atrial remodeling and subsequent arrhythmogenesis [62]

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