Group for Research and Assessment of Psoriasis and Psoriatic Arthritis - GRAPPA gathers more than 1,000 thought leaders committed to better understanding and treating psoriasis and psoriatic arthritis
0.51 mg (5001,000 mcg) once daily by subcutaneous injection, often run as 48 week cycles
This drug increased secretion of gelsolin, antithrombotic protein, by EAT, modulated CD11b on neutrophils, its migration and endothelial adhesion, induced by adiposity protein, FABP4, or a chemoattractant
Common side effects (affect 30-70% of users): Testosterone suppression/shutdown: Your natural testosterone production stops Testicles shrink (reduced function) Fertility problems (sometimes permanent) Requires post-cycle therapy (PCT) to recover Some users never fully recover natural production Cardiovascular issues: Increased blood pressure (often significantly) Altered cholesterol (lower HDL, higher LDL) Left ventricular hypertrophy (enlarged heart) Increased heart attack and stroke risk Risk accumulates with each cycle Liver stress (oral steroids): Elevated liver enzymes Potential liver damage with prolonged use Some orals are extremely hepatotoxic Hormonal side effects: Gynecomastia (male breast tissue growth) Acne (often severe on back/chest) Hair loss (if genetically predisposed) Oily skin Mood changes, aggression, anxiety Other common issues: Sleep disruption Increased appetite (some compounds) Bloating and water retention Increased body temperature Night sweats Less common but serious: Psychological effects: Mood swings and irritability ("roid rage" is real for some) Depression during cycle or post-cycle Anxiety and paranoia Body dysmorphia worsening Dependency issues Organ damage: Kidney stress (especially with high doses) Prostate enlargement Potential cardiovascular remodeling (permanent) Metabolic issues: Insulin resistance (some compounds) Diabetes risk increase Thyroid disruption The dose-response problem: Higher doses = better results BUT exponentially worse side effects
Wegovy is used in addition to a reduced-calorie diet and increased physical activity
These medications can improve glucose levels by reducing variability
