Starting at the full 2.4 mg dose would produce severe nausea, vomiting, and other gastrointestinal distress in most individuals
A daily dose of 2.5 to 5 milligrams is commonly recommended
303 Interestingly, intracerebroventricular administration of GLP-1 did not inhibit feeding in GLP-1R knockout mice but did in wild-type mice, suggesting that GLP-1R signalling mediates satiety, although no evidence for abnormal body weight or feeding behaviour was reported in GLP-1R knockout mice
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In future work, the team plans to expand beyond Reddit and English-language discussions to confirm whether the same symptoms appear across different social media platforms and populations
[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Lund E.G., Guileyardo J.M., Russell D.W