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Upregulating Myc, SOX2, OCT4, and KLF4 in cardiomyocytes prior to and during MI can promote the dedifferentiation of mature cardiomyocytes, thereby reactivating the cell cycle and enhancing myocardial regeneration

As the terminal stage of various CVDs, HF is associated with a persistently high rate of morbidity, hospital readmission, and mortality in patients and has become a major public health problem worldwide, with more than 60 million cases diagnosed globally (90)

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Detailed information about these SNPs is in Additional file 1: Table S2

Boosts production of elastin, a protein that helps skin stretch and bounce back, improving its elasticity and resilience