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Unknown is not the same as safe

After entering one-carbon metabolism, Ser can promote the generation of SAM, thereby affecting the status of DNA/histone methylation and reshaping inflammatory gene expression programs (64)

Additionally, a high concentration of alkaline solution is needed to neutralize the acidity after centrifugation

These areas of investigation are of particular relevance: NNMT Interaction

The choice depends on peptide sensitivity and user requirements for shelf life