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doi:10.1210/en.2009-0989 Madsbad S, Kielgast U, Asmar M, Deacon CF, Torekov SS, Holst JJ

Protect GLP-1 from rapid breakdown by the enzyme DPP-4, extending its activity

Providers typically consider several things before approving the next stage of escalation, including whether side effects appeared during the prior stage, current body weight, kidney and liver function, and any other medications a patient is taking

doi:10.1210/me.2008-0201