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When to Seek Provider Guidance on Tirzepatide Response Patients should contact their healthcare provider if weight loss stalls within the first 8 weeks at therapeutic doses, if new or worsening gastrointestinal symptoms develop, or if underlying conditions (thyroid disease, polycystic ovary syndrome, uncontrolled diabetes) are discovered

However, federal law does not require state-licensed pharmacies that are not outsourcing facilities to submit adverse events to FDA so it is likely that adverse events from compounded versions of these drugs are underreported

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It also helps coordinate daily fluctuations in hormone release, metabolism, and body temperature, among other physiological processes

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doi: 10.1038/bjc.1995.482