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11 For further reading on the extensive subject of G6PD deficiency, we refer the reader to excellent reviews.17,41,107,189 6-Phosphogluconate Dehydrogenase (Decarboxylating) (EC 1.1.1.44) Even though the oxidation of phosphogluconate to ribulose 5-phosphate by 6-phosphogluconate dehydrogenase generates one mole of NADPH, the few cases of 6-phosphogluconate dehydrogenase deficiency usually are not associated with hemolysis