Raju, P
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While its precise etiology remains unclear, growing evidence implicates oxidative stress and mitochondrial dysfunction as key contributors to its pathophysiology ( Oxidative stress results from an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, leading to cellular damage, lipid peroxidation, mitochondrial dysfunction, and neuroinflammationall of which may exacerbate pain sensitization and fatigue in FM ( Mitochondrial dysfunction in Redox imbalance is marked by decreased CoQ10 levels, reduced mitochondrial DNA content, and impaired electron transport chain activity, leading to excessive ROS production and decreased ATP synthesis
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After pregnancy, your body is coping with many postpartum transitions, such as hormonal rebalancing and breast size changes
All molecules from the FDA approved drugs DrugBank subset and known inhibitors were subjected to the Openeye Blockbuster filter (part of the OMEGA suite version 4.1.2.0) to remove non-druglike compounds and limit the production of spurious hits [29]
